Signal transduction pathways in acne and acne variants - Role of dietary intervention
| Autor(en): | Melnik, B. | Stichwörter: | growth hormone, 36992-73-1, 37267-05-3, 66419-50-9, 9002-72-6; somatomedin C, 67763-96-6; Acne pathogenesis; article; cigarette smoking; diet; Dietary intervention; FoxO1; growth factor; growth hormone; human; insulin like activity; pathogenesis; protein secretion; puberty; retinoid; signal transduction; somatomedin C; transcription factor FOXO, acne | Erscheinungsdatum: | 2010 | Journal: | Nederlands Tijdschrift voor Dermatologie en Venereologie | Volumen: | 20 | Ausgabe: | 4 | Startseite: | 168 | Seitenende: | 169 | Zusammenfassung: | All major pathogenetic factors of acne and acne variants are explained at the genomic level by a nuclear deficiency of the transcription factor FoxO1 due to increased growth factor signaling either by elevated secretion of growth hormone/IGF-1 during puberty or increased growth factor-like acneigenic stimuli and insulinotropic western nutrition. Retinoid therapy and dietary intervention compensate the nuclear FoxO1 deficiency. |
ISSN: | 09258604 | Externe URL: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-78249267933&partnerID=40&md5=90312f0b3b852884ad04798753af8e18 |
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