PH and Acne

DC FieldValueLanguage
dc.contributor.authorSchürer, N.
dc.date.accessioned2021-12-23T16:33:57Z-
dc.date.available2021-12-23T16:33:57Z-
dc.date.issued2018
dc.identifier.issn14215721
dc.identifier.urihttps://osnascholar.ub.uni-osnabrueck.de/handle/unios/17928-
dc.description.abstractAcne is based on a complex, multifactorial pathophysiology beginning with a microcomedo. Comedogenesis involves follicular hyperproliferation and disturbed keratinization, hyperseborrhea and hyperplasia of sebaceous glands as well as disturbances in skin microbiome. Acne is treated with antibiotics, retinoids, keratolytics, hormonal and anti-inflammatory agents. Efficacy and side effects of given medications are well known. The uppermost layer of the stratum corneum is acidic. The low pH provides protection by slowing down the growth of some bacteria. Increase of skin surface pH leads to impaired barrier function, disturbances in skin microbiome and inflammation. Acne-predisposed skin is in a constant state of subclinical inflammation. Subclinical inflammation may be linked to changes in skin surface pH and disturbances of the stratum corneum, allowing microorganisms to stimulate the production of pro-inflammatory cytokines. Here, based on the current literature, the possible link between the skin surface pH, epidermal barrier function and acne is reviewed. © Copyright 2018 S. Karger AG, Basel. All rights reserved.
dc.language.isoen
dc.publisherS. Karger AG
dc.relation.ispartofCurrent Problems in Dermatology (Switzerland)
dc.subjectacne
dc.subjectArticle
dc.subjecthuman
dc.subjectpH
dc.subjectpriority journal
dc.subjectPropionibacterium acnes
dc.subjectskin surface
dc.subjectstratum corneum
dc.subjectacne vulgaris
dc.subjectaging
dc.subjectanimal
dc.subjectchemistry
dc.subjectfemale
dc.subjectgrowth, development and aging
dc.subjectmale
dc.subjectmetabolism
dc.subjectpathogenicity
dc.subjectpH
dc.subjectsexual characteristics
dc.subjectskin
dc.subjectskin pigmentation, Acne Vulgaris
dc.subjectAging
dc.subjectAnimals
dc.subjectFemale
dc.subjectHumans
dc.subjectHydrogen-Ion Concentration
dc.subjectMale
dc.subjectPropionibacterium acnes
dc.subjectSex Characteristics
dc.subjectSkin
dc.subjectSkin Pigmentation
dc.titlePH and Acne
dc.typejournal article
dc.identifier.doi10.1159/000489525
dc.identifier.pmid30130780
dc.identifier.scopus2-s2.0-85052190415
dc.identifier.urlhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85052190415&doi=10.1159%2f000489525&partnerID=40&md5=53e0647b361c1b046aeeae8adbd5cc75
dc.description.volume54
dc.description.startpage115
dc.description.endpage122
dcterms.isPartOf.abbreviationCurr. Probl. Dermatol.
crisitem.author.deptFB 08 - Humanwissenschaften-
crisitem.author.deptidfb08-
crisitem.author.parentorgUniversität Osnabrück-
crisitem.author.netidScNa997-
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