New possibilities for the structure determination of membrane proteins [Neue Möglichkeiten für die Strukturbestimmung von Membranproteinen]

Abstract

Membrane proteins establish the connection between the outside and the inside of a cell. Even though 30 percent of proteins in a cell are membrane associated, their structural data is strongly underrepresented due to the high flexibility and low purification yield. The resolution revolution in cryo-EM opened up new opportunities to solve structures of dynamic membrane proteins that can only be purified in small quantities. © 2020, Die Autoren.