The P450 system and mTORC1 signalling in acne

Autor(en): Melnik, Bodo C.
Stichwörter: acne; ACTIVATION; androgens; cytochrome P450; CYTOCHROME-P450; Dermatology; ERYTHROMYCIN; EXPRESSION; FoxO1; HUMAN SEBOCYTES; HUMAN SKIN; INHIBITION; KERATINOCYTES; METABOLISM; mTORC1; retinoic acid; TRANS-RETINOIC ACID
Erscheinungsdatum: 2014
Herausgeber: WILEY
Journal: EXPERIMENTAL DERMATOLOGY
Volumen: 23
Ausgabe: 5
Startseite: 318
Seitenende: 319
Zusammenfassung: 
In this issue, Hellmann-Regen etal. suggested that anti-acne effects of erythromycin and tetracyclines may be related to their inhibitory effect of cytochrome P450-mediated degradation of all-trans-retinoic acid (ATRA). We have recently proposed that all anti-acne agents function by attenuation of increased mTORC1 signalling. This commentary links the P450 system to mTORC1 regulation in acne. Drug-mediated induction of P450 activity or P450 mutants with increased catabolic activity may reduce cellular ATRA levels and FoxO1 expression, thus reducing FoxO-mediated mTORC1 inhibition. In contrast, agents blocking ATRA degradation such as erythromycin and tetracyclines may improve acne by increasing FoxO1 expression with consecutive inhibition of mTORC1 signalling.
ISSN: 09066705
DOI: 10.1111/exd.12359

Show full item record

Google ScholarTM

Check

Altmetric