Modeling specific action potentials in the human atria based on a minimal single-cell model

Autor(en): Richter, Yvonne
Lind, Pedro G.
Maass, Philipp 
Stichwörter: CURRENTS; FIBRILLATION; INSIGHTS; Multidisciplinary Sciences; Science & Technology - Other Topics
Erscheinungsdatum: 2018
Herausgeber: PUBLIC LIBRARY SCIENCE
Journal: PLOS ONE
Volumen: 13
Ausgabe: 1
Zusammenfassung: 
We present an effective method to model empirical action potentials of specific patients in the human atria based on the minimal model of Bueno-Orovio, Cherry and Fenton adapted to atrial electrophysiology. In this model, three ionic are currents introduced, where each of it is governed by a characteristic time scale. By applying a nonlinear optimization procedure, a best combination of the respective time scales is determined, which allows one to reproduce specific action potentials with a given amplitude, width and shape. Possible applications for supporting clinical diagnosis are pointed out.
ISSN: 19326203
DOI: 10.1371/journal.pone.0190448

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