Yeast vacuole fusion - A model system for eukaryotic endomembrane dynamics

Autor(en): Ostrowicz, Clemens W.
Meiringer, Christoph T. A.
Ungermann, Christian 
Stichwörter: Cell Biology; DISTINCT SNARE COMPLEXES; endomembrane; fusion; HOPS; IN-VITRO REACTIONS; INTRACELLULAR MEMBRANE-FUSION; LATE STEP; lysosome; PROTEIN-TRANSPORT; RETICULUM-GOLGI TRANSPORT; SACCHAROMYCES-CEREVISIAE; SEC17P ALPHA-SNAP; SNARE; T-SNARE; vacuole; VERTEX RING DOMAIN
Erscheinungsdatum: 2008
Herausgeber: LANDES BIOSCIENCE
Journal: AUTOPHAGY
Volumen: 4
Ausgabe: 1
Startseite: 5
Seitenende: 19
Zusammenfassung: 
Vesicular transport in eukaryotic cells is concluded with the consumption of the vesicle at the target membrane. This fusion process relies on Rabs, tethers and SNAREs. Powerful in vitro fusion systems using isolated organelles were crucial to obtain insights into the underlying mechanism of membrane fusion from the initiation of fusion to lipid bilayer mixing. Among these systems, yeast vacuoles turned out to be particularly useful as they can be manipulated biochemically and genetically. Studies relying on this organelle have revealed insights into the connection of vacuole fusion to endomembrane biogenesis. A number of fusion factors were identified and characterized over the last several years, and placed into the fusion cascade. Within this review, we will present and discuss the current state of our knowledge on vacuole fusion.
ISSN: 15548627
DOI: 10.4161/auto.5054

Show full item record

Page view(s)

2
Last Week
0
Last month
0
checked on Mar 2, 2024

Google ScholarTM

Check

Altmetric