Nucleosides and oligonucleotides with diynyl side chains: The Huisgen-Sharpless cycloaddition ``click reaction'' performed on DNA and their constituents
| Autor(en): | Seela, Frank Sirivolu, Venkata Rarnana |
Stichwörter: | Biochemistry & Molecular Biology; cycloaddition; dipropargyl ether; DUPLEX STABILITY; nucleosides; octadiynyl; phosphoramidites; PYRIMIDINES | Erscheinungsdatum: | 2007 | Herausgeber: | TAYLOR & FRANCIS INC | Enthalten in: | NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | Band: | 26 | Ausgabe: | 6-7 | Startseite: | 597 | Seitenende: | 601 | Zusammenfassung: | Phosphoramidite building blocks related to the four canonical DNA constituents and oligonucleotides with octadiynyl side chains (5b-8b) or dipropargyl ether residues (5c) were synthesized. Nucleosides and oligonucleotides were functionalized at the terminal triple bonds employing the Huisgen-Sharpless cycloaddition `' click reaction `'. |
Beschreibung: | Proceedings of the 17th International Roundtable of Nucleosides, Nucleotides, and Nucleic Acids, Bern, SWITZERLAND, MAR 07-SEP 07, 2006 |
ISSN: | 15257770 | DOI: | 10.1080/15257770701490308 |
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