Nucleosides and oligonucleotides with diynyl side chains: The Huisgen-Sharpless cycloaddition ``click reaction'' performed on DNA and their constituents

Autor(en): Seela, Frank
Sirivolu, Venkata Rarnana
Stichwörter: Biochemistry & Molecular Biology; cycloaddition; dipropargyl ether; DUPLEX STABILITY; nucleosides; octadiynyl; phosphoramidites; PYRIMIDINES
Erscheinungsdatum: 2007
Herausgeber: TAYLOR & FRANCIS INC
Journal: NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
Volumen: 26
Ausgabe: 6-7
Startseite: 597
Seitenende: 601
Zusammenfassung: 
Phosphoramidite building blocks related to the four canonical DNA constituents and oligonucleotides with octadiynyl side chains (5b-8b) or dipropargyl ether residues (5c) were synthesized. Nucleosides and oligonucleotides were functionalized at the terminal triple bonds employing the Huisgen-Sharpless cycloaddition `' click reaction `'.
Beschreibung: 
Proceedings of the 17th International Roundtable of Nucleosides, Nucleotides, and Nucleic Acids, Bern, SWITZERLAND, MAR 07-SEP 07, 2006
ISSN: 15257770
DOI: 10.1080/15257770701490308

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