7-deaza-2 `-deoxy-7-propynylguanosine

DC FieldValueLanguage
dc.contributor.authorSeela, F
dc.contributor.authorShaikh, K
dc.contributor.authorEickmeier, H
dc.date.accessioned2021-12-23T15:56:42Z-
dc.date.available2021-12-23T15:56:42Z-
dc.date.issued2004
dc.identifier.issn01082701
dc.identifier.urihttps://osnascholar.ub.uni-osnabrueck.de/handle/unios/2482-
dc.description.abstractThe title compound, C14H16N4O4, adopts the anti conformation at the glycosylic bond [chi = 117.1 (5)degrees]. The sugar pucker of the 2'-deoxyribofuranosyl moiety is C2'-endo-C3'-exo, T-2(3) (S-type). The orientation of the exocyclic C4'-C5' bond is sc (gauche). The propynyl group is linear and coplanar with the nucleobase moiety. The structure of the compound is stabilized by several hydrogen bonds (N - H ... O and O - H ... O), leading to the formation of a multi-layered network. The nucleobases, as well as the propynyl groups, are stacked. This stacking might cause the extraordinary stability of DNA duplexes containing this compound.
dc.language.isoen
dc.publisherBLACKWELL MUNKSGAARD
dc.relation.ispartofACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS
dc.subject2'-DEOXYGUANOSINE
dc.subject7-DEAZA-2'-DEOXYGUANOSINE
dc.subjectChemistry
dc.subjectChemistry, Multidisciplinary
dc.subjectCRYSTAL
dc.subjectCrystallography
dc.subjectDNA
dc.subjectNUCLEIC-ACIDS
dc.subjectNUCLEOSIDES
dc.subjectOLIGODEOXYNUCLEOTIDES
dc.subjectOLIGONUCLEOTIDES
dc.subjectPROPYNE ANALOGS
dc.subjectRECOGNITION
dc.title7-deaza-2 `-deoxy-7-propynylguanosine
dc.typejournal article
dc.identifier.doi10.1107/S0108270104011552
dc.identifier.isiISI:000222429900036
dc.description.volume60
dc.description.issue7
dc.description.startpageO489-O491
dc.publisher.place35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK
dcterms.isPartOf.abbreviationActa Crystallogr. Sect. C-Cryst. Struct. Commun.
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