Parallel DNA containing pyrazolo[3,4-D]pyrimidine analogues of isoguanine

Autor(en): Seela, F
Kroschel, R
He, Y
Stichwörter: Biochemistry & Molecular Biology
Erscheinungsdatum: 2001
Herausgeber: MARCEL DEKKER INC
Journal: NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
Volumen: 20
Ausgabe: 4-7
Startseite: 1283
Seitenende: 1286
Zusammenfassung: 
The phosphoramidites of 8-aza-7-deaza-2'-deoxyisoguanosine (1a) and its bromo derivative 1b as well as of 6-aza-2-deoxyisocytidine and its 5-methyl derivative (3a,b) were synthesized. Parallel-stranded duplexes containing the nucleosides 1a,b show a significantly enhanced duplex stability compared to those containing 2'-deoxyisoguanosine.
Beschreibung: 
XIVth International Roundtable on Nucleosides, Nucleotides and their Biological Applications, SAN FRANCISCO, CALIFORNIA, SEP 10-14, 2000
ISSN: 15257770
DOI: 10.1081/NCN-100002537

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