Oligonucleotide duplex stability controlled by the 7-substituents of 7-deazaguanine bases
| Autor(en): | Seela, F Ramzaeva, N Chen, YM |
Stichwörter: | Chemistry; Chemistry, Medicinal; Chemistry, Organic; DNA; Pharmacology & Pharmacy | Erscheinungsdatum: | 1995 | Herausgeber: | PERGAMON-ELSEVIER SCIENCE LTD | Enthalten in: | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | Band: | 5 | Ausgabe: | 24 | Startseite: | 3049 | Seitenende: | 3052 | Zusammenfassung: | Oligonucleotides containing 7-substituted 7-deazaguanine residues (7-methyl, 7-iodol have been synthesized. The self-complementary octamer d(I(7)c(7)G-C)(4) containing 7-iodo-7-deaza-2'-deoxyguanosine forms a stabilized duplex compared to the parent oligomer d(G-C)(4) (Delta T-m = 10 degrees C). Also the complex between the oligodeoxynucleotide d(I(7)c(7)G(5)-G) and poly(C) is stabilized (Delta T-m = 10 degrees) over that of d(c(7)G(5)-G) with poly(C). |
ISSN: | 0960894X | DOI: | 10.1016/0960-894X(95)00535-X |
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