Oligonucleotide duplex stability controlled by the 7-substituents of 7-deazaguanine bases

Autor(en): Seela, F
Ramzaeva, N
Chen, YM
Stichwörter: Chemistry; Chemistry, Medicinal; Chemistry, Organic; DNA; Pharmacology & Pharmacy
Erscheinungsdatum: 1995
Herausgeber: PERGAMON-ELSEVIER SCIENCE LTD
Journal: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volumen: 5
Ausgabe: 24
Startseite: 3049
Seitenende: 3052
Zusammenfassung: 
Oligonucleotides containing 7-substituted 7-deazaguanine residues (7-methyl, 7-iodol have been synthesized. The self-complementary octamer d(I(7)c(7)G-C)(4) containing 7-iodo-7-deaza-2'-deoxyguanosine forms a stabilized duplex compared to the parent oligomer d(G-C)(4) (Delta T-m = 10 degrees C). Also the complex between the oligodeoxynucleotide d(I(7)c(7)G(5)-G) and poly(C) is stabilized (Delta T-m = 10 degrees) over that of d(c(7)G(5)-G) with poly(C).
ISSN: 0960894X
DOI: 10.1016/0960-894X(95)00535-X

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