GLUTAMATE-ACTIVATED IONIC CURRENTS IN CULTURED ASTROCYTES FROM TROUT - EVIDENCE FOR THE OCCURRENCE OF NON-N-METHYL-D-ASPARTATE RECEPTORS

Autor(en): CLASEN, T
JESERICH, G
KRUPPEL, T
Stichwörter: BONY FISHES; BRAIN; CHANNELS; EXCITATORY AMINO-ACIDS; GLIAL-CELLS; MEMBRANE; NEUROGLIA; NEURONS; Neurosciences; Neurosciences & Neurology; NEUROTRANSMITTER; OLIGODENDROCYTES; POTASSIUM; WHOLE-CELL CLAMP
Erscheinungsdatum: 1995
Herausgeber: WILEY-LISS
Journal: JOURNAL OF NEUROSCIENCE RESEARCH
Volumen: 40
Ausgabe: 5
Startseite: 632
Seitenende: 640
Zusammenfassung: 
Glutamate-induced currents were recorded from cultured trout astrocytes with the whole-cell variation of the patch-clamp technique. Ninety percent of the tested cells were directly depolarized by the amino acid neurotransmitter in a concentration-dependent manner, The depolarizing effect was due to an inward current that reversed near 0 mV and was accompanied by a noise increase, indicating the opening of an ion channel, Ion substitution experiments revealed that the glutamate-induced current was mainly carried by sodium ions but not chloride or calcium ions, The glutamate-induced response could be mimicked by the neuronal glutamate receptor subtype agonists kainate and quisqualate, while N-methyl-D-aspartate was without detectable effect. (c) 1995 Wiley-Liss, Inc.
ISSN: 03604012
DOI: 10.1002/jnr.490400508

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