On the Morphology of the Drosophila Heart

DC FieldValueLanguage
dc.contributor.authorRotstein, Barbara
dc.contributor.authorPaululat, Achim
dc.date.accessioned2021-12-23T15:57:39Z-
dc.date.available2021-12-23T15:57:39Z-
dc.date.issued2016
dc.identifier.issn23083425
dc.identifier.urihttps://osnascholar.ub.uni-osnabrueck.de/handle/unios/3050-
dc.description.abstractThe circulatory system of Drosophila melanogaster represents an easily amenable genetic model whose analysis at different levels, i.e., from single molecules up to functional anatomy, has provided new insights into general aspects of cardiogenesis, heart physiology and cardiac aging, to name a few examples. In recent years, the Drosophila heart has also attracted the attention of researchers in the field of biomedicine. This development is mainly due to the fact that several genes causing human heart disease are also present in Drosophila, where they play the same or similar roles in heart development, maintenance or physiology as their respective counterparts in humans. This review will attempt to briefly introduce the anatomy of the Drosophila circulatory system and then focus on the different cell types and non-cellular tissue that constitute the heart.
dc.description.sponsorshipDFG (Collaborative Research Center)German Research Foundation (DFG) [SFB944/TP7, PA517/12-1]; State of Lower-Saxony [ZN2832]; We thank Chris Kirchner for his assistance in drawing the 3D structure of the adult heart. We are grateful toW. Mangerich and K. Etzold for their technical handling. We are in debt to all those students, which worked in our lab, for sharing unpublished pictures. In particular, we thank M. Reinhardt (Figure 2(C2)), K. Lammers (Figure 4), C. Kommnick (Figure 5) and C. Walter (Figure 7). A.P. received support from the DFG (Collaborative Research Center SFB944/TP7 &. PA517/12-1) and from the State of Lower-Saxony (ZN2832).
dc.language.isoen
dc.publisherMDPI
dc.relation.ispartofJOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
dc.subjectCardiac & Cardiovascular Systems
dc.subjectcardiovascular system
dc.subjectCardiovascular System & Cardiology
dc.subjectcirculatory system
dc.subjectdorsal vessel
dc.subjectDrosophila melanogaster
dc.subjectheart
dc.titleOn the Morphology of the Drosophila Heart
dc.typereview
dc.identifier.doi10.3390/jcdd3020015
dc.identifier.isiISI:000457904100005
dc.description.volume3
dc.description.issue2
dc.contributor.orcid0000-0002-8845-6859
dc.publisher.placeST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
dcterms.isPartOf.abbreviationJ. Cardiovasc. Dev. Dis.
dcterms.oaStatusGreen Published, Green Submitted, gold
crisitem.author.deptFB 05 - Biologie/Chemie-
crisitem.author.deptidfb05-
crisitem.author.orcid0000-0002-8845-6859-
crisitem.author.parentorgUniversität Osnabrück-
crisitem.author.netidPaAc947-
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