A conceptual model describing the fate of sulfadiazine and its metabolites observed in manure-amended soils

DC FieldValueLanguage
dc.contributor.authorZarfl, Christiane
dc.contributor.authorKlasmeier, Joerg
dc.contributor.authorMatthies, Michael
dc.date.accessioned2021-12-23T15:58:42Z-
dc.date.available2021-12-23T15:58:42Z-
dc.date.issued2009
dc.identifier.issn00456535
dc.identifier.urihttps://osnascholar.ub.uni-osnabrueck.de/handle/unios/3517-
dc.description.abstractSulfadiazine (SDZ) belongs to the chemical class of sulfonamides, one of the most important groups of antibiotics applied in animal husbandry in Europe. These antibiotics end up in the soil after manure from treated animals is applied as fertilizer. They can inhibit soil microbial functions and enhance the spread of resistance genes among soil microorganisms. in order to assess the exposure of soil microorganisms to SDZ, a conceptual kinetic model for the prediction of temporally resolved antibiotic concentrations in soil was developed. The model includes transformation reactions. reversible Sequestration and the formation of non-extractable residues (NER) from SDZ and its main metabolites N-4-acetyl-sulfadiazine (N-ac-SDZ) and 4-hydroxy-sulfadiazine (OH-SDZ). The optimum model structure and rate constants of SDZ kinetics and its metabolites were determined by fitting different model alternatives to sequential extraction data of a manure-amended Cambisol soil. N-ac-SDZ is degraded to SDZ with a half-life of 4 d, whereas OH-SDZ is not. Though, based on the available data, the hydroxylation of SDZ seems to be negligible, it is still included in the model structure since this process has been observed in recent studies. Sequestration into a residual fraction has similar kinetics for SDZ, N-ac-SDZ and OH-SDZ and is one order of magnitude faster than the reverse translocation. The irreversible formation of NER is restricted to SDZ and OH-SDZ. The model shows good agreement when applied to extraction data measured independently for a Luvisol soil. The combination of sequential extraction data and the conceptual kinetic model enables us to gain further insight into the long-term fate and exposure of sulfonamides in soil. (C) 2009 Elsevier Ltd. All rights reserved.
dc.description.sponsorshipGerman Research Foundation (DFG)German Research Foundation (DFG); Hans Muhlenhoff Foundation; We would like to thank our colleagues from the Division of Soil Science, University of Bonn, in particular Markus Forster, Volker Laabs and Wulf Amelung, for providing the extraction data. We also thank our colleague Andreas Focks for his fruitful discussions. Financial support by the German Research Foundation (DFG) and the Hans Muhlenhoff Foundation is gratefully acknowledged.
dc.language.isoen
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.relation.ispartofCHEMOSPHERE
dc.subjectBIOAVAILABILITY
dc.subjectBIODEGRADATION
dc.subjectEnvironmental Sciences
dc.subjectEnvironmental Sciences & Ecology
dc.subjectExtractability
dc.subjectORGANIC CONTAMINANTS
dc.subjectPig manure
dc.subjectRESIDUES
dc.subjectSequestration
dc.subjectSLURRY
dc.subjectSoil sorption
dc.subjectSORPTION
dc.subjectSULFONAMIDE ANTIMICROBIAL AGENTS
dc.subjectTRANSPORT
dc.subjectTRIMETHOPRIM
dc.subjectVETERINARY ANTIBIOTICS
dc.subjectVeterinary medicines
dc.titleA conceptual model describing the fate of sulfadiazine and its metabolites observed in manure-amended soils
dc.typejournal article
dc.identifier.doi10.1016/j.chemosphere.2009.08.035
dc.identifier.isiISI:000271301300003
dc.description.volume77
dc.description.issue6
dc.description.startpage720
dc.description.endpage726
dc.contributor.orcid0000-0002-2044-1335
dc.identifier.eissn18791298
dc.publisher.placeTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
dcterms.isPartOf.abbreviationChemosphere
crisitem.author.deptInstitut für Umweltsystemforschung-
crisitem.author.deptidresearchcenter5-
crisitem.author.parentorgUniversität Osnabrück-
crisitem.author.netidKlJo590-
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