Fungal homologues of human Rac1 as emerging players in signal transduction and morphogenesis

DC FieldValueLanguage
dc.contributor.authorHuehn, Julia
dc.contributor.authorMusielak, Marius
dc.contributor.authorSchmitz, Hans-Peter
dc.contributor.authorHeinisch, Juergen J.
dc.date.accessioned2021-12-23T15:58:54Z-
dc.date.available2021-12-23T15:58:54Z-
dc.date.issued2020
dc.identifier.issn11396709
dc.identifier.urihttps://osnascholar.ub.uni-osnabrueck.de/handle/unios/3633-
dc.description.abstractA wealth of data is accumulating on the physiological functions of human Rac1, a member of the Rho GTPase family of molecular switches and substrate of botulinum toxin, which was first identified as a regulator of cell motility through its effect on the actin cytoskeleton. Later on, it was found to be involved in different diseases like cancers, cardiac function, neuronal disorders, and apoptotic cell death. Despite the presence of Rac1 homologues in most fungi investigated so far, including Rho5 in the genetically tractable model yeast Saccharomyces cerevisiae, knowledge on their physiological functions is still scarce, let alone the details of the molecular mechanisms of their actions and interactions. Nevertheless, all functions proposed for human Rac1 seem to be conserved in one or the other fungus. This includes the regulation of MAPK cascades, polarized growth, and actin dynamics. Moreover, both the production and response to reactive oxygen species, as well as the reaction to nutrient availability, can be affected. We here summarize the studies performed on fungal Rac1 homologues, with a special focus on S. cerevisiae Rho5, which may be of use in drug development in medicine and agriculture.
dc.description.sponsorshipDeutsche Forschungsgemeinschaft (DFG)German Research Foundation (DFG) [HE 1880/6-1]; Work in our laboratory related to this review has been financed by a grant from the Deutsche Forschungsgemeinschaft (DFG; grant HE 1880/6-1) to J.J.H.
dc.language.isoen
dc.publisherSPRINGER
dc.relation.ispartofINTERNATIONAL MICROBIOLOGY
dc.subjectBiotechnology & Applied Microbiology
dc.subjectCDC42
dc.subjectFilamentous fungi
dc.subjectG-PROTEINS
dc.subjectGTPase
dc.subjectHYPHAE
dc.subjectMicrobiology
dc.subjectPATHOGENICITY
dc.subjectPATHWAY
dc.subjectRAS
dc.subjectREGULATE POLARIZED GROWTH
dc.subjectRHO GTPASES
dc.subjectRho5
dc.subjectSACCHAROMYCES-CEREVISIAE
dc.subjectSignaling
dc.subjectSMALL GTPASES
dc.subjectYeast
dc.titleFungal homologues of human Rac1 as emerging players in signal transduction and morphogenesis
dc.typereview
dc.identifier.doi10.1007/s10123-019-00077-1
dc.identifier.isiISI:000513243400005
dc.description.volume23
dc.description.issue1, SI
dc.description.startpage43
dc.description.endpage53
dc.contributor.orcid0000-0001-5449-4593
dc.contributor.researcheridG-3801-2017
dc.identifier.eissn16181905
dc.publisher.placeONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
dcterms.isPartOf.abbreviationInt. Microbiol.
crisitem.author.deptFB 05 - Biologie/Chemie-
crisitem.author.deptidfb05-
crisitem.author.orcid0000-0001-5449-4593-
crisitem.author.parentorgUniversität Osnabrück-
crisitem.author.netidScHa130-
Show simple item record

Page view(s)

6
Last Week
0
Last month
0
checked on Apr 17, 2024

Google ScholarTM

Check

Altmetric