Chitin synthesis inhibitors: old molecules and new developments

Autor(en): Merzendorfer, Hans 
Stichwörter: 2-SPOTTED SPIDER-MITE; acaricide; benzoylurea; CALCOFLUOR WHITE; chitin synthesis inhibitor; CONGO RED; cuticle; Entomology; etoxazole; IN-VITRO; INSECT GROWTH-REGULATORS; insecticide; MOLTED AMERICAN COCKROACH; PERITROPHIC MATRIX; POLYOXINS ANTIFUNGAL ANTIBIOTICS; RED FLOUR BEETLE; TETRANYCHUS-URTICAE
Erscheinungsdatum: 2013
Herausgeber: WILEY
Journal: INSECT SCIENCE
Volumen: 20
Ausgabe: 2
Startseite: 121
Seitenende: 138
Zusammenfassung: 
Chitin is the most abundant natural aminopolysaccharide and serves as a structural component of extracellular matrices. It is found in fungal septa, spores, and cell walls, and in arthropod cuticles and peritrophic matrices, squid pens, mollusk shells, nematode egg shells, and some protozoan cyst walls. As prokaryotes, plants and vertebrates including humans do not produce chitin, its synthesis is considered as an attractive target site for fungicides, insecticides, and acaricides. Although no chitin synthesis inhibitor has been developed into a therapeutic drug to treat fungal infections in humans, a larger number of compounds have been successfully launched worldwide to combat arthropod pests in agriculture and forestry. This review summarizes the latest advances on the mode of action of chitin synthesis inhibitors with a special focus on those molecules that act on a postcatalytic step of chitin synthesis.
ISSN: 16729609
DOI: 10.1111/j.1744-7917.2012.01535.x

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