Chitin synthesis inhibitors: old molecules and new developments

DC FieldValueLanguage
dc.contributor.authorMerzendorfer, Hans
dc.date.accessioned2021-12-23T15:58:56Z-
dc.date.available2021-12-23T15:58:56Z-
dc.date.issued2013
dc.identifier.issn16729609
dc.identifier.urihttps://osnascholar.ub.uni-osnabrueck.de/handle/unios/3652-
dc.description.abstractChitin is the most abundant natural aminopolysaccharide and serves as a structural component of extracellular matrices. It is found in fungal septa, spores, and cell walls, and in arthropod cuticles and peritrophic matrices, squid pens, mollusk shells, nematode egg shells, and some protozoan cyst walls. As prokaryotes, plants and vertebrates including humans do not produce chitin, its synthesis is considered as an attractive target site for fungicides, insecticides, and acaricides. Although no chitin synthesis inhibitor has been developed into a therapeutic drug to treat fungal infections in humans, a larger number of compounds have been successfully launched worldwide to combat arthropod pests in agriculture and forestry. This review summarizes the latest advances on the mode of action of chitin synthesis inhibitors with a special focus on those molecules that act on a postcatalytic step of chitin synthesis.
dc.description.sponsorshipDeutsche ForschungsgemeinschaftGerman Research Foundation (DFG) [ME2210/3-1]; I thank Dr. Subbaratnam Muthukrishnan for reading the manuscript and for his useful comments and suggestions. This work was supported by grant ME2210/3-1 from the Deutsche Forschungsgemeinschaft.
dc.language.isoen
dc.publisherWILEY
dc.relation.ispartofINSECT SCIENCE
dc.subject2-SPOTTED SPIDER-MITE
dc.subjectacaricide
dc.subjectbenzoylurea
dc.subjectCALCOFLUOR WHITE
dc.subjectchitin synthesis inhibitor
dc.subjectCONGO RED
dc.subjectcuticle
dc.subjectEntomology
dc.subjectetoxazole
dc.subjectIN-VITRO
dc.subjectINSECT GROWTH-REGULATORS
dc.subjectinsecticide
dc.subjectMOLTED AMERICAN COCKROACH
dc.subjectPERITROPHIC MATRIX
dc.subjectPOLYOXINS ANTIFUNGAL ANTIBIOTICS
dc.subjectRED FLOUR BEETLE
dc.subjectTETRANYCHUS-URTICAE
dc.titleChitin synthesis inhibitors: old molecules and new developments
dc.typereview
dc.identifier.doi10.1111/j.1744-7917.2012.01535.x
dc.identifier.isiISI:000316698600001
dc.description.volume20
dc.description.issue2
dc.description.startpage121
dc.description.endpage138
dc.identifier.eissn17447917
dc.publisher.place111 RIVER ST, HOBOKEN 07030-5774, NJ USA
dcterms.isPartOf.abbreviationInsect Sci.
crisitem.author.deptFB 05 - Biologie/Chemie-
crisitem.author.deptidfb05-
crisitem.author.parentorgUniversität Osnabrück-
crisitem.author.netidMeHa731-
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