Cellular microcompartments constitute general suborganellar functional units in cells

Autor(en): Holthuis, Joost C. M.
Ungermann, Christian 
Stichwörter: BACTERIAL MICROCOMPARTMENTS; Biochemistry & Molecular Biology; cellular microcompartment; ENDOPLASMIC-RETICULUM; FLIGHT-MUSCLE; LATE ENDOSOME; LIPID RAFTS; membrane domain; microdomain; MITOCHONDRIA; molecular scaffold, organelle; ORGANELLE CONTACT SITES; ORGANIZATION; PLASMA-MEMBRANE; PROTEINS
Erscheinungsdatum: 2013
Herausgeber: WALTER DE GRUYTER & CO
Journal: BIOLOGICAL CHEMISTRY
Volumen: 394
Ausgabe: 2
Startseite: 151
Seitenende: 161
Zusammenfassung: 
All cells are compartmentalized to facilitate enzymatic reactions or cellular dynamics. In eukaryotic cells, organelles differ in their protein/lipid repertoire, luminal ion composition, pH, and redox status. In addition, organelles contain specialized subcompartments even within the same membrane or within its lumen. Moreover, the bacterial plasma membrane reveals a remarkable degree of organization, which is recapitulated in eukaryotic cells and often linked to cell signaling. Finally, protein-based compartments are also known in the bacterial and eukaryotic cytosol. As the organizing principle of such cellular subcompartments is likely similar, previous definitions like rafts, microdomains, and all kinds of `-somes' fall short as a general denominator to describe such suborganellar structures. Within this review, we will introduce the term cellular microcompartment as a general suborganellar functional unit and discuss its relevance to understand subcellular organization and function.
ISSN: 14316730
DOI: 10.1515/hsz-2012-0265

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