OLIGODEOXYRIBONUCLEOTIDES CONTAINING N-7-(2-DEOXY-BETA-D-ERYTHRO-PENTOFURANOSYL)ADENINE
| Autor(en): | SEELA, F WINTER, H |
Stichwörter: | Chemistry; Chemistry, Medicinal; Chemistry, Organic; DNA; GLYCOSYLATION; Pharmacology & Pharmacy | Erscheinungsdatum: | 1993 | Herausgeber: | PERGAMON-ELSEVIER SCIENCE LTD | Enthalten in: | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | Band: | 3 | Ausgabe: | 2 | Startseite: | 273 | Seitenende: | 276 | Zusammenfassung: | The synthesis of N7-(2-deoxy-beta-D-erythro-pentofuranosyl)adenine (7A(d), 1) is described. Compound 1 was protected at the 6-amino group with the dimethylaminomethylidene residue (3a), the DMT group was selected for OH-5' protection (3b) and the 3'-phosphonate 3c was prepared. Solid-phase synthesis employing 3c furnished oligonucleotides containing 7A(d). |
ISSN: | 0960894X | DOI: | 10.1016/S0960-894X(01)80891-X |
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