OLIGODEOXYRIBONUCLEOTIDES CONTAINING N-7-(2-DEOXY-BETA-D-ERYTHRO-PENTOFURANOSYL)ADENINE

Autor(en): SEELA, F
WINTER, H
Stichwörter: Chemistry; Chemistry, Medicinal; Chemistry, Organic; DNA; GLYCOSYLATION; Pharmacology & Pharmacy
Erscheinungsdatum: 1993
Herausgeber: PERGAMON-ELSEVIER SCIENCE LTD
Journal: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volumen: 3
Ausgabe: 2
Startseite: 273
Seitenende: 276
Zusammenfassung: 
The synthesis of N7-(2-deoxy-beta-D-erythro-pentofuranosyl)adenine (7A(d), 1) is described. Compound 1 was protected at the 6-amino group with the dimethylaminomethylidene residue (3a), the DMT group was selected for OH-5' protection (3b) and the 3'-phosphonate 3c was prepared. Solid-phase synthesis employing 3c furnished oligonucleotides containing 7A(d).
ISSN: 0960894X
DOI: 10.1016/S0960-894X(01)80891-X

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