Acid survival of Helicobacter pylori: how does urease activity trigger cytoplasmic pH homeostasis?

Autor(en): Stingl, K
Altendorf, K 
Bakker, EP
Stichwörter: ACIDOPHILIC BACTERIA; Biochemistry & Molecular Biology; CATION; DIFFERENCE; ESCHERICHIA-COLI-CELLS; MEMBRANE; Microbiology; MOTIVE FORCE; PROTON ELECTROCHEMICAL GRADIENT; RESISTANCE; SEQUENCE; TRANSPORT
Erscheinungsdatum: 2002
Herausgeber: ELSEVIER SCIENCE LONDON
Journal: TRENDS IN MICROBIOLOGY
Volumen: 10
Ausgabe: 2
Startseite: 70
Seitenende: 74
Zusammenfassung: 
Helicobacter pylori can survive for several hours at pH 1 in the presence of urea. Under these conditions, the organism maintains its cytoplasmic pH at a value close to neutral. The role of the cytoplasmically located urease enzyme in this process is a matter of debate. We propose that cytoplasmic ammonia generated by the action of urease is protonated by H+ ions leaking in from the acidic medium and that the NH4+ formed is extruded from the cytoplasm via an as-yet-unidentified transport system. This mechanism is compared with the general mechanism of cytoplasmic pH homeostasis in microorganisms.
ISSN: 0966842X
DOI: 10.1016/S0966-842X(01)02287-9

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