Salmonella enterica Remodels the Host Cell Endosomal System for Efficient Intravacuolar Nutrition

Autor(en): Liss, Viktoria
Swart, A. Leoni
Kehl, Alexander
Hermanns, Natascha
Zhang, Yuying
Chikkaballi, Deepak
Boehles, Nathalie
Deiwick, Joerg
Hensel, Michael 
Stichwörter: BACTERIAL VIRULENCE; DYNAMICS; GENES; IDENTIFICATION; III SECRETION SYSTEM; INDUCED FILAMENTS; Microbiology; Parasitology; PATHOGENICITY ISLAND 2; REVEALS; TRAFFICKING; TYPHIMURIUM; Virology
Erscheinungsdatum: 2017
Herausgeber: CELL PRESS
Journal: CELL HOST & MICROBE
Volumen: 21
Ausgabe: 3
Startseite: 390
Seitenende: 402
Zusammenfassung: 
Salmonella enterica is a facultative intracellular pathogen that survives and proliferates in the Salmonella-containing vacuole (SCV), yet how these vacuolar bacteria acquire nutrition remains to be determined. Intracellular Salmonella convert the host endosomal system into an extensive network of interconnected tubular vesicles, of which Salmonella-induced filaments (SIFs) are the most prominent. We found that membranes and lumen of SIFs and SCVs form a continuum, giving vacuolar Salmonella access to various types of endocytosed material. Membrane proteins and luminal content rapidly diffuse between SIFs and SCVs. Salmonella in SCVs without connection to SIFs have reduced access to endocytosed components. On a single-cell level, Salmonella within the SCV-SIF continuum were found to exhibit higher metabolic activity than vacuolar bacteria lacking SIFs. Our data demonstrate that formation of the SCV-SIF continuum allows Salmonella to bypass nutritional restriction in the intracellular environment by acquiring nutrients from the host cell endosomal system.
ISSN: 19313128
DOI: 10.1016/j.chom.2017.02.005

Show full item record

Page view(s)

2
Last Week
0
Last month
2
checked on Feb 28, 2024

Google ScholarTM

Check

Altmetric