Pyrazolo[3,4-d]pyrimidine nucleic acids: Ajustment of the dA-dT to the dG-dC base pair stability
| Autor(en): | He, J Becher, G Budow, S Seela, F |
Stichwörter: | Biochemistry & Molecular Biology; DNA | Erscheinungsdatum: | 2003 | Herausgeber: | MARCEL DEKKER INC | Journal: | NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | Volumen: | 22 | Ausgabe: | 5-8 | Startseite: | 573 | Seitenende: | 576 | Zusammenfassung: | The pyrazolo[3,4-d]pyrimidine-4,6-diamine nucleosides 2b-d stabilize the dA-dT base pair significantly when the dA-residue is replaced. Oligonucleotide duplexes incorporating 2b-d show a 4-6degreesC T-m increase per modification. The 7-bromo compound 2b harmonizes the stability of the dA-dT vs. the dG-dC pair. According to this the stability Of Such duplexes depends no longer on the base pair composition of a DNA molecule. |
Beschreibung: | 15th International Roundtable Meeting on Nucleosides, Nucleotides and Nucleic Acids, LEUVEN, BELGIUM, SEP 10-14, 2002 |
ISSN: | 15257770 | DOI: | 10.1081/NCN-120021957 |
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