Pyrazolo[3,4-d]pyrimidine nucleic acids: Ajustment of the dA-dT to the dG-dC base pair stability

Autor(en): He, J
Becher, G
Budow, S
Seela, F
Stichwörter: Biochemistry & Molecular Biology; DNA
Erscheinungsdatum: 2003
Herausgeber: MARCEL DEKKER INC
Journal: NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
Volumen: 22
Ausgabe: 5-8
Startseite: 573
Seitenende: 576
Zusammenfassung: 
The pyrazolo[3,4-d]pyrimidine-4,6-diamine nucleosides 2b-d stabilize the dA-dT base pair significantly when the dA-residue is replaced. Oligonucleotide duplexes incorporating 2b-d show a 4-6degreesC T-m increase per modification. The 7-bromo compound 2b harmonizes the stability of the dA-dT vs. the dG-dC pair. According to this the stability Of Such duplexes depends no longer on the base pair composition of a DNA molecule.
Beschreibung: 
15th International Roundtable Meeting on Nucleosides, Nucleotides and Nucleic Acids, LEUVEN, BELGIUM, SEP 10-14, 2002
ISSN: 15257770
DOI: 10.1081/NCN-120021957

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