DC Element | Wert | Sprache |
dc.contributor.author | Seela, F | |
dc.contributor.author | Leonard, P | |
dc.date.accessioned | 2021-12-23T15:59:50Z | - |
dc.date.available | 2021-12-23T15:59:50Z | - |
dc.date.issued | 1998 | |
dc.identifier.issn | 0018019X | |
dc.identifier.uri | https://osnascholar.ub.uni-osnabrueck.de/handle/unios/4167 | - |
dc.description.abstract | Oligonucleotides containing N-7-(2'-deoxy-beta-D-erythro-pentofuranosyl)adenine (1),-hypoxanthine (2), and -guanine (3) were synthesized on solid-phase using phosphonate and phosphoramidite chemistry. As part of the synthesis of compound 2. the nucleobase-anion glycosylation of various 6-alkoxypurines with 2-droxy-3,5-di-O-(4-toluoyl)-alpha-D-erythro-pentofuranosyl chloride (5) was investigated. The duplex stability of oligonucleotides containing N-7-glycosylated purines opposite to regular pyrimidines was determined, and thermodynamic data were calculated from melting profiles. Oligodeoxyribonucleotide duplexes containing N-7-glycosylated adenine T-d or N-7-glycosylated guanine Cd base pairs are more stable in the case of parallel strand orientation than in the case of antiparallel chains. | |
dc.language.iso | en | |
dc.publisher | WILEY-V C H VERLAG GMBH | |
dc.relation.ispartof | HELVETICA CHIMICA ACTA | |
dc.subject | BUILDING-BLOCKS | |
dc.subject | Chemistry | |
dc.subject | Chemistry, Multidisciplinary | |
dc.subject | DEOXYINOSINE | |
dc.subject | GLYCOSYLATION | |
dc.subject | N-7-(2-DEOXY-BETA-D-ERYTHRO-PENTOFURANOSYL)GUANINE N(7)G(D) | |
dc.subject | OLIGODEOXYRIBONUCLEOTIDES | |
dc.subject | OLIGONUCLEOTIDES | |
dc.subject | RECOGNITION | |
dc.subject | SOLID-PHASE SYNTHESIS | |
dc.subject | STABILITY | |
dc.subject | TRIPLE-HELIX FORMATION | |
dc.title | N-7-DNA: Base-pairing properties of N-7-(2 `-deoxy-beta-D-erythro-pentofuranosyl)-substituted adenine, hypoxanthine, and guanine in duplexes with parallel chain orientation | |
dc.type | journal article | |
dc.identifier.isi | ISI:000077817900006 | |
dc.description.volume | 81 | |
dc.description.issue | 12 | |
dc.description.startpage | 2244 | |
dc.description.endpage | 2263 | |
dc.publisher.place | BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY | |
dcterms.isPartOf.abbreviation | Helv. Chim. Acta | |