Isoguanine quartets formed by d(T(4)isoG(4)T(4)): Tetraplex identification and stability

Autor(en): Seela, F
Wei, CF
Melenewski, A
Stichwörter: BASE-PAIR; Biochemistry & Molecular Biology; CHROMATOGRAPHY; DNA; FRAGMENTS; ISOGUANOSINE
Erscheinungsdatum: 1996
Herausgeber: OXFORD UNIV PRESS
Journal: NUCLEIC ACIDS RESEARCH
Volumen: 24
Ausgabe: 24
Startseite: 4940
Seitenende: 4945
Zusammenfassung: 
The self-aggregation of the oligonucleotide d(T(4)isoG(4)T(4)) (1) is investigated. Based on ion exchange HPLC experiments and CD spectroscopy, a tetrameric structure is identified, This structure was formed in the presence of sodium ions and shows almost the same chromatographic mobility on ion exchange HPLC as d(T(4)G(4)T(4)) (2) The ratio of aggregate versus monomer is temperature dependent and the tetraplex of [d(T(4)isoG(4)T(4))](4) is more stable than that of [d(T(4)G(4)T(4))](4) A mixture of d(T(4)isoG(4)T(4)) and d(T(4)G(4)T(4)) forms mixed tetraplexes containing strands of d(T(4)isoG(4)T(4)) and d(T(4)G(4)T(4)).
ISSN: 03051048
DOI: 10.1093/nar/24.24.4940

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