8-aza-7-deazapurine DNA: Synthesis and duplex stability of oligonucleotides containing 7-substituted bases
| Autor(en): | Seela, F Becher, G Zulauf, M |
Stichwörter: | Biochemistry & Molecular Biology | Erscheinungsdatum: | 1999 | Herausgeber: | MARCEL DEKKER INC | Journal: | NUCLEOSIDES & NUCLEOTIDES | Volumen: | 18 | Ausgabe: | 6-7 | Startseite: | 1399 | Seitenende: | 1400 | Zusammenfassung: | The 7-substituted 8-aza-7-deazapurine phosphoramidites 1a - 3c as well as the phosphoramidite 4a were synthesized. In comparison to the parent purine oligonucleotide duplexes, the 7-substituted 8-aza-7-deazapurine residues lead to a significant duplex stabilization. |
Beschreibung: | XIII International Round Table Conference on Nucleosides, Nucleotides and their Biological Applications, MONTPELLIER, FRANCE, SEP 06-10, 1998 |
ISSN: | 07328311 | DOI: | 10.1080/07328319908044730 |
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