Mitsunobu Alkylation of Cancerostatic 5-Fluorouridine with (2E)-10-Hydroxydec-2-enoic Acid, a Fatty Acid from Royal Jelly with Multiple Biological Activities

Autor(en): Ottenhaus, Vanessa
Rosemeyer, Helmut 
Stichwörter: 5-FLUORO-2'-DEOXYURIDINE; Biochemistry & Molecular Biology; BIOMIMETIC LIPOPHILIZATION; Chemistry; Chemistry, Multidisciplinary; CYTOSTATIC 5-FLUOROURIDINE; DRUG DISCOVERY; FTORAFUR; IN-VITRO; NUCLEIC-ACIDS; OLIGONUCLEOTIDES; THYMIDINE; TUMORS
Erscheinungsdatum: 2015
Herausgeber: WILEY-V C H VERLAG GMBH
Journal: CHEMISTRY & BIODIVERSITY
Volumen: 12
Ausgabe: 9
Startseite: 1307
Seitenende: 1312
Zusammenfassung: 
5-Fluorouridine (1) - a nucleoside antimetabolite with strong cancerostatic properties - was protected i) at the 2'-and 3'-OH groups with a heptan-4-ylidene residue and ii) at the 5'-OH group with a (4-methoxyphenyl)(diphenyl) methyl residue. This fully protected compound, 3, was submitted to a Mitsunobu reaction with the N-hydroxysuccinimide (NHS) ester, 5, of (2E)-10-hydroxydec-2-enoic acid (4) which gave nucleolipid 6. The latter was detritylated with Cl2CHCOOH to yield the co-drug 7 as NHS ester.
ISSN: 16121872
DOI: 10.1002/cbdv.201500048

Show full item record

Page view(s)

2
Last Week
0
Last month
2
checked on Mar 2, 2024

Google ScholarTM

Check

Altmetric