Synthesis and base pairing properties of 9-deazapurine N-7-nucleosides in oligonucleotide duplexes and triplexes

Abstract

The 9-deazaguanine N-7-2'-deoxyribofuranoside (3) as well as the bromo and iodo derivatives 4a,b were synthesized and incorporated in oligonculeotide duplexes and triplexes. Their base pairing properties were investigated and compared with those of the parent purine N-7-2'-deoxyribofuanosides.