Oligonucleotides with purine nitrogen-7 as glycosylation site

Abstract

The synthesis of phosphoramidites (2 and 3) derived from hypoxanthine and isoguanine N-7-2'-deoxyribonucleosides is described. Solid-phase synthesis furnishes oligonucleotides containing N-7-glycosylated purines. New base pairs between purine N-7- and N(z)9-nucleosides are proposed.