Vacuole membrane contact sites and domains: emerging hubs to coordinate organelle function with cellular metabolism

DC FieldValueLanguage
dc.contributor.authorMalia, Pedro Carpio
dc.contributor.authorUngermann, Christian
dc.date.accessioned2021-12-23T16:01:03Z-
dc.date.available2021-12-23T16:01:03Z-
dc.date.issued2016
dc.identifier.issn03005127
dc.identifier.urihttps://osnascholar.ub.uni-osnabrueck.de/handle/unios/4743-
dc.description.abstractEukaryotic cells rely on a set of membrane-enclosed organelles to perform highly efficient reactions in an optimized environment. Trafficking of molecules via vesicular carriers and membrane contact sites (MCS) allow the coordination between these compartments, though the precise mechanisms are still enigmatic. Among the cellular organelles, the lysosome/vacuole stands out as a central hub, where multiple pathways merge. Importantly, the delivered material is degraded and the monomers are recycled for further usage, which explains its wide variety of roles in controlling cellular metabolism. We will highlight recent advances in the field by focusing on the yeast vacuole as a model system to understand lysosomal function in general.
dc.description.sponsorshipDeutsche Forschungsgemeinschaft (DFG)German Research Foundation (DFG) [UN111/10-1]; This work was supported by the Deutsche Forschungsgemeinschaft (DFG) [grant number UN111/10-1].
dc.language.isoen
dc.publisherPORTLAND PRESS LTD
dc.relation.ispartofBIOCHEMICAL SOCIETY TRANSACTIONS
dc.subjectBiochemistry & Molecular Biology
dc.subjectENDOSOME
dc.subjectFUSION
dc.subjectIBAR
dc.subjectIvy1
dc.subjectLYSOSOME BIOGENESIS
dc.subjectmicrodomain
dc.subjectMITOCHONDRIA
dc.subjectnuclear-vacuolar junction (NVJ)
dc.subjectNUCLEUS
dc.subjectOXYSTEROL-BINDING PROTEIN
dc.subjectTETHERING COMPLEX
dc.subjectTORC1
dc.subjectVAC8P
dc.subjectvacuole
dc.subjectvCLAMP
dc.subjectYEAST SACCHAROMYCES-CEREVISIAE
dc.titleVacuole membrane contact sites and domains: emerging hubs to coordinate organelle function with cellular metabolism
dc.typereview
dc.identifier.doi10.1042/BST20150277
dc.identifier.isiISI:000377518000030
dc.description.volume44
dc.description.issue2
dc.description.startpage528
dc.description.endpage533
dc.identifier.eissn14708752
dc.publisher.placeCHARLES DARWIN HOUSE, 12 ROGER STREET, LONDON WC1N 2JU, ENGLAND
dcterms.isPartOf.abbreviationBiochem. Soc. Trans.
crisitem.author.netidUnCh999-
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