7-deaza-2 `-deoxyguanosine

Autor(en): Seela, F
Shaikh, KI
Eickmeier, H
Stichwörter: 2'-DEOXYGUANOSINE; Chemistry; Chemistry, Multidisciplinary; Crystallography; DNA; DUPLEX STABILITY; NUCLEIC-ACIDS; NUCLEOSIDES; OLIGODEOXYNUCLEOTIDES; OLIGONUCLEOTIDES; RECOGNITION
Erscheinungsdatum: 2005
Herausgeber: WILEY-BLACKWELL
Journal: ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS
Volumen: 61
Ausgabe: 3
Startseite: O151-O153
Zusammenfassung: 
In the title compound, 2-amino-7-(2-deoxy-beta-D-erythropentofuranosyl)-3,7-dihydropyrrolo[2, 3-d]pyrimidin-4-one, C(11)H(14)N(4)O(4), the N-glycosylic bond torsion angle, chi, is anti [-106.5 (3)degrees]. The 2'-deoxyribofuranosyl moiety adopts the (3)T(4) (N-type) conformation, with P = 39.1degrees and tau(m) = 40.3degrees. The conformation around the exocyclic C-C bond is ap (trans), with a torsion angle, gamma, of -173.8 (3)degrees. The nucleoside forms a hydrogen-bonded network, leading to a close-packed multiple-layer structure with a head-to-head arrangement of the bases. The nucleobase interplanar O =C-C ... NH(2) distance is 3.441 (1) Angstrom.
ISSN: 01082701
DOI: 10.1107/S0108270105000971

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