Cell fate decisions in the Drosophila dorsal vessel depend on the multiadapter protein inscuteable

Autor(en): Popichenko, D
Paululat, A 
Stichwörter: asymmetric cell division; Developmental Biology; DIVISIONS; dorsal vessel; Drosophila; EMBRYOGENESIS; GENE; Genetics & Heredity; HEART; Inscuteable; Mef2; MESODERM; MUSCLES; NOTCH; NUMB; Odd-skipped; SUBSET; TINMAN
Erscheinungsdatum: 2004
Herausgeber: WILEY
Journal: GENESIS
Volumen: 40
Ausgabe: 4
Startseite: 218
Seitenende: 222
Zusammenfassung: 
The Drosophila dorsal vessel consists of two cell types, contractile cardiomyoblasts that form a linear tube-like structure, and the loosely associated pericardial cells. All heart cells originate during embryogenesis from the early dorsal mesoderm under the influence of external and internal signals. Recently, it was shown that a subset of heart cells arise throughout asymmetric cell division, dependent on the function of Notch, Sanpodo, and Numb. Here, we show that Inscuteable, a multiadapter protein required for asymmetric cell division, participates in the formation of specific heart cells to distinguish between a myogenic (cardiomyoblast) and a nonmyogenic (pericardial cell) fate. (C) 2004 Wiley-Liss, Inc.
ISSN: 1526954X
DOI: 10.1002/gene.20080

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