STEREOSPECIFIC OXIDATION OF RP-DINUCLEOSIDE AND SP-DINUCLEOSIDE H-PHOSPHONATES TO PHOSPHOROTHIOATES

Autor(en): SEELA, F
KRETSCHMER, U
Stichwörter: Biochemistry & Molecular Biology
Erscheinungsdatum: 1991
Herausgeber: MARCEL DEKKER INC
Journal: NUCLEOSIDES & NUCLEOTIDES
Volumen: 10
Ausgabe: 1-3
Startseite: 711
Seitenende: 712
Zusammenfassung: 
8 H-Phosphonate dimers with dA, dC, dG or dT at the 5'- and dA or dT at the 3'-end were synthesized and separated into their diastereoisomers. Sulfur oxidation of the optically pure compounds proved to be stereospecific leading to R(p) or S(p) phosphorothioates.
Beschreibung: 
9TH INTERNATIONAL ROUND TABLE ON NUCLEOSIDES, NUCLEOTIDES, AND THEIR BIOLOGICAL APPLICATIONS, UPPSALA, SWEDEN, JUL 30-AUG 03, 1990
ISSN: 07328311
DOI: 10.1080/07328319108046578

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