STEREOSPECIFIC OXIDATION OF RP-DINUCLEOSIDE AND SP-DINUCLEOSIDE H-PHOSPHONATES TO PHOSPHOROTHIOATES
| Autor(en): | SEELA, F KRETSCHMER, U |
Stichwörter: | Biochemistry & Molecular Biology | Erscheinungsdatum: | 1991 | Herausgeber: | MARCEL DEKKER INC | Journal: | NUCLEOSIDES & NUCLEOTIDES | Volumen: | 10 | Ausgabe: | 1-3 | Startseite: | 711 | Seitenende: | 712 | Zusammenfassung: | 8 H-Phosphonate dimers with dA, dC, dG or dT at the 5'- and dA or dT at the 3'-end were synthesized and separated into their diastereoisomers. Sulfur oxidation of the optically pure compounds proved to be stereospecific leading to R(p) or S(p) phosphorothioates. |
Beschreibung: | 9TH INTERNATIONAL ROUND TABLE ON NUCLEOSIDES, NUCLEOTIDES, AND THEIR BIOLOGICAL APPLICATIONS, UPPSALA, SWEDEN, JUL 30-AUG 03, 1990 |
ISSN: | 07328311 | DOI: | 10.1080/07328319108046578 |
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