Elucidating biochemical features and biological roles of Streptomyces proteins recognizing crystalline chitin- and cellulose-types and their soluble derivatives

Autor(en): Schrempf, Hildgund 
Stichwörter: ABC TRANSPORTER NGC; ALPHA-CHITIN; BINDING-PROTEIN; Biochemistry & Molecular Biology; Chemistry; Chemistry, Applied; Chemistry, Organic; DEGRADER; FUNCTIONAL-CHARACTERIZATION; LYTIC POLYSACCHARIDE MONOOXYGENASE; N-ACETYLGLUCOSAMINE; OLIVACEOVIRIDIS; RETICULI; SYSTEM
Erscheinungsdatum: 2017
Herausgeber: ELSEVIER SCI LTD
Journal: CARBOHYDRATE RESEARCH
Volumen: 448
Startseite: 220
Seitenende: 226
Zusammenfassung: 
Pioneering biochemical, immunological, physiological and microscopic studies in combination with gene cloning allowed uncovering previously unknown genes encoding proteins of streptomycetes to target crystalline chitin and cellulose as well as their soluble degradation-compounds via binding protein dependent transporters. Complementary analyses provoked an understanding of novel regulators governing transcription of selected genes. These discoveries induced detecting close and distant homologues of former orphan proteins encoded by genes from different bacteria. Grounded on structure-function relationships, several researchers identified a few of these proteins as novel members of the growing family for lytic polysaccharides monooxygenases. Exemplary, the ecological significance of the characterized proteins including their role to promote interactions among organisms is outlined and discussed. (C) 2017 Elsevier Ltd. All rights reserved.
ISSN: 00086215
DOI: 10.1016/j.carres.2017.06.010

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