Rab cascades and tethering factors in the endomembrane system

Autor(en): Markgraf, Daniel F.
Peplowska, Karolina
Ungermann, Christian 
Stichwörter: Biochemistry & Molecular Biology; Biophysics; Cell Biology; EFFECTOR; endomembrane; ENDOSOME; GOLGI; GUANINE-NUCLEOTIDE EXCHANGE; PERIPHERAL MEMBRANE-PROTEIN; Rab cascade; rab effector; Rab GTPases; SECRETORY VESICLES; SMALL GTPASE; SNARE COMPLEX; SPECIFICITY; tethering factor; TRAPP; vesicular transport
Erscheinungsdatum: 2007
Herausgeber: WILEY
Journal: FEBS LETTERS
Volumen: 581
Ausgabe: 11
Startseite: 2125
Seitenende: 2130
Zusammenfassung: 
Rab GTPases are key proteins that determine organelle identity and operate at the center of fusion reactions. Like Ras, they act as switches that are connected to a diverse network of tethering factors, exchange factors and GTPase activating proteins. Recent studies suggest that Rabs are linked to each other via their effectors, thus coordinating protein transport in the endomembrane system. Within this review, we will focus on selected examples that highlight these issues. (C) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
ISSN: 00145793
DOI: 10.1016/j.febslet.2007.01.090

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