6-amino-3-bromo-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-1,5-dihydro -4H-pyrazolo[3,4-d]pyrimidin-4-one-acetone-water (1/1/1): a fluorinated 2 `-deoxyguanosine analogue with the sugar conformation of a ribonucleoside
| Autor(en): | He, JL Eickmeier, H Seela, F |
Stichwörter: | AGENTS; Chemistry; Chemistry, Multidisciplinary; CRYSTAL; Crystallography; GAUCHE; HIV; NUCLEOSIDES; RNA; STABILITY | Erscheinungsdatum: | 2003 | Herausgeber: | BLACKWELL MUNKSGAARD | Journal: | ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS | Volumen: | 59 | Ausgabe: | 7 | Startseite: | O406-O408 | Zusammenfassung: | In the title compound, C10H11BrFN5O4.C3H6O.H2O, the N-glycosylic bond torsion angle, chi, is anti [-108.0 (4)degrees]. The sugar pucker is N-type [C2'-exo, E-2 with P = 346.5 (4)degrees and tau(m) = 34.5 (2)degrees], and the conformation around the C-C bond linking the CH2 group and the furan ring is -sc [torsion angle gamma = -70.0 (4)degrees]. |
ISSN: | 01082701 | DOI: | 10.1107/S0108270103011430 |
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