6-amino-3-bromo-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-1,5-dihydro -4H-pyrazolo[3,4-d]pyrimidin-4-one-acetone-water (1/1/1): a fluorinated 2 `-deoxyguanosine analogue with the sugar conformation of a ribonucleoside

Autor(en): He, JL
Eickmeier, H
Seela, F
Stichwörter: AGENTS; Chemistry; Chemistry, Multidisciplinary; CRYSTAL; Crystallography; GAUCHE; HIV; NUCLEOSIDES; RNA; STABILITY
Erscheinungsdatum: 2003
Herausgeber: BLACKWELL MUNKSGAARD
Journal: ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS
Volumen: 59
Ausgabe: 7
Startseite: O406-O408
Zusammenfassung: 
In the title compound, C10H11BrFN5O4.C3H6O.H2O, the N-glycosylic bond torsion angle, chi, is anti [-108.0 (4)degrees]. The sugar pucker is N-type [C2'-exo, E-2 with P = 346.5 (4)degrees and tau(m) = 34.5 (2)degrees], and the conformation around the C-C bond linking the CH2 group and the furan ring is -sc [torsion angle gamma = -70.0 (4)degrees].
ISSN: 01082701
DOI: 10.1107/S0108270103011430

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