7-iodo-8-aza-7-deaza-2 `-deoxyadenosine and 7-bromo-8-aza-7-deaza-2 `-deoxyadenosine
| Autor(en): | Seela, F Zulauf, M Reuter, H Kastner, C |
Stichwörter: | Chemistry; Chemistry, Multidisciplinary; CONFORMATION; Crystallography; NUCLEOSIDES; OLIGONUCLEOTIDES; STABILITY | Erscheinungsdatum: | 2000 | Herausgeber: | MUNKSGAARD INT PUBL LTD | Journal: | ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS | Volumen: | 56 | Ausgabe: | 4 | Startseite: | 489 | Seitenende: | 491 | Zusammenfassung: | The isomorphous structures of the title molecules, 4-amino-1-(2-deoxy-beta-D-erythro-pentofuranosyl)-3-iodo-1H-pyrazolo-[ 3,4-d]pyrimidine, (I), C10H12IN5O3, and 4-amino-3-bromo-1-(2-deoxy-beta-D-erythro-pentofuranosyl)-1H-pyrazolo[ 3,4-d]pyrimidine, (II), C10H12BrN5O3, have been determined. The sugar puckering of both compounds is C1'-endo (E-1'). The N-glycosidic bond torsion angle chi(1) is in the high-anti range [-73.2(4)degrees for (I) and -74.1 (4)degrees for (II)] and the crystal structure is stabilized by hydrogen bonds. |
ISSN: | 01082701 |
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