Incorporation of 2 `-deoxysangivamycin in DNA duplexes: The conversion of a pyrrolo[2,3-d]pyrimidine nitrile to a carboxamide upon oligonucleotide deprotection
| Autor(en): | Seela, F Zulauf, M |
Stichwörter: | 2'-DEOXYTUBERCIDIN; ANALOGS; Biochemistry & Molecular Biology; DERIVATIVES; MAJOR GROOVE; NUCLEOSIDES; NUCLEOTIDES; OLIGODEOXYNUCLEOTIDES; OLIGODEOXYRIBONUCLEOTIDES; SALT GLYCOSYLATION PROCEDURE; TUBERCIDIN | Erscheinungsdatum: | 1999 | Herausgeber: | MARCEL DEKKER INC | Enthalten in: | NUCLEOSIDES & NUCLEOTIDES | Band: | 18 | Ausgabe: | 11-12 | Startseite: | 2697 | Seitenende: | 2709 | Zusammenfassung: | Oligonucleotides containing 2'-deoxysangivamycin are described. The phosphoramidite of 2'-deoxytoyocamycin was prepared and used in solid-phase synthesis. Upon deprotection the pyrrolo[2,3-d]pyrimidine nitrile residues were converted to carboxamides. According to the T-m-measurements the 7-carboxamido group of the 7-deazaadenine moiety stabilizes the DNA duplex significantly. |
ISSN: | 07328311 | DOI: | 10.1080/07328319908044635 |
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geprüft am 07.06.2024
