1-DEAZA-2'-DEOXYADENOSINE - PHOSPHONATE AND PHOSPHORAMIDITE BUILDING-BLOCKS FOR SOLID-PHASE OLIGONUCLEOTIDE SYNTHESIS

DC FieldValueLanguage
dc.contributor.authorSEELA, F
dc.contributor.authorWENZEL, T
dc.date.accessioned2021-12-23T16:02:33Z-
dc.date.available2021-12-23T16:02:33Z-
dc.date.issued1993
dc.identifier.issn03855414
dc.identifier.urihttps://osnascholar.ub.uni-osnabrueck.de/handle/unios/5472-
dc.description.abstractThe synthesis of the 3'-[(2-cyanoethyl)diisopropylphosphoramidite] (3b) and the 3'-phosphonate (3a) of 1-deaza-2'-deoxyadenosine (1b) is described. For this purpose compound lb was protected at the 6-amino group with a benzoyl residue. Ensuing 4,4'-dimethoxytritylation of lb and phosphitylation afforded the P(III) derivatives(3a) and (3b). They were successfully employed in solid-phase oligodeoxyribonucleotide synthesis of d(c1A-c1A-c1A-A-A-A) (6). C-13-Nmr and N-15-nmr spectra of the compounds (1-5) are discussed.
dc.language.isoen
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.relation.ispartofHETEROCYCLES
dc.subjectChemistry
dc.subjectChemistry, Organic
dc.subjectDEOXYNUCLEOSIDES
dc.subjectDNA
dc.subjectRIBONUCLEOSIDES
dc.title1-DEAZA-2'-DEOXYADENOSINE - PHOSPHONATE AND PHOSPHORAMIDITE BUILDING-BLOCKS FOR SOLID-PHASE OLIGONUCLEOTIDE SYNTHESIS
dc.typejournal article
dc.identifier.doi10.3987/COM-92-6214
dc.identifier.isiISI:A1993KH49500004
dc.description.volume36
dc.description.issue2
dc.description.startpage237
dc.description.endpage242
dc.publisher.placeTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB
dcterms.isPartOf.abbreviationHeterocycles
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