Evaluation of a dominant-negative recombinant herpes simplex virus (HSV) type 1 as a vaccine against genital herpes in mice und guinea pigs
DC Element | Wert | Sprache |
---|---|---|
dc.contributor.author | Brans, R. | |
dc.date.accessioned | 2021-12-23T16:02:40Z | - |
dc.date.available | 2021-12-23T16:02:40Z | - |
dc.date.issued | 2010 | |
dc.identifier.issn | 00178470 | |
dc.identifier.uri | https://osnascholar.ub.uni-osnabrueck.de/handle/unios/5549 | - |
dc.description.abstract | Genital herpes caused by herpes simplex virus (HSV) is one of the most common sexually transmitted diseases worldwide. Currently, no safe and effective vaccine against HSV is available. CJ9-gD is a completely replication-defective HSV-1 recombinant which inhibits replication of wild-type HSV-1/-2 in co-infected cells (dominant-negative effect). Moreover, it expresses high levels of HSV-1 major antigen glycoprotein D (gD). Immunization with CJ9-gD induces strong and long-lasting humoral and Th1-like cellular immune responses against both HSV-1 and HSV-2 in mice protecting immunized animals significantly against genital challenge with HSV-1 or HSV-2. Guinea pigs immunized with CJ9-gD were significantly protected against primary and recurrent HSV-2 genital disease and latent infection. | |
dc.language.iso | de | |
dc.publisher | SPRINGER | |
dc.relation.ispartof | HAUTARZT | |
dc.subject | Dermatology | |
dc.subject | DISEASE | |
dc.subject | Genital herpes | |
dc.subject | Glycoprotein D | |
dc.subject | GLYCOPROTEIN-D | |
dc.subject | Herpes simplex virus | |
dc.subject | HSV | |
dc.subject | INFECTION | |
dc.subject | PREVENTION | |
dc.subject | Replication defective | |
dc.title | Evaluation of a dominant-negative recombinant herpes simplex virus (HSV) type 1 as a vaccine against genital herpes in mice und guinea pigs | |
dc.type | journal article | |
dc.identifier.doi | 10.1007/s00105-010-2075-8 | |
dc.identifier.isi | ISI:000284894200015 | |
dc.description.volume | 61 | |
dc.description.issue | 12 | |
dc.description.startpage | 1073 | |
dc.description.endpage | 1077 | |
dc.publisher.place | 233 SPRING ST, NEW YORK, NY 10013 USA | |
dcterms.isPartOf.abbreviation | Hautarzt | |
crisitem.author.dept | Universität Osnabrück | - |
crisitem.author.orcid | 0000-0002-1245-024X | - |
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geprüft am 01.06.2024