Modified purine nucleosides as dangling ends of DNA duplexes: the effect of the nucleobase polarizability on stacking interactions

DC FieldValueLanguage
dc.contributor.authorRosemeyer, H
dc.contributor.authorSeela, F
dc.date.accessioned2021-12-23T16:03:00Z-
dc.date.available2021-12-23T16:03:00Z-
dc.date.issued2002
dc.identifier.issn1472779X
dc.identifier.urihttps://osnascholar.ub.uni-osnabrueck.de/handle/unios/5745-
dc.description.abstractBase-modified nucleotide residues have been appended to the 5'-terminus of the self-complementary oligo-2'-deoxynucleotide duplex [5'-d(CGCGCG)](2) as dangling ends. Temperature-dependent UV measurements on the resulting oligomers indicate generally higher thermal stabilities (T-m) compared to that without an overhanging end. The duplex stabilization (DeltaT(m)) was correlated with the molecular polarizability (a(m)) of the base of the pendant nucleoside showing that: the higher the molecular polarizability a(m) of a dangling nucleobase, the higher the thermal stability of the DNA duplex.
dc.language.isoen
dc.publisherROYAL SOC CHEMISTRY
dc.relation.ispartofJOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2
dc.subjectACID
dc.subjectAFFINITY
dc.subjectAROMATIC STACKING
dc.subjectBASE-PAIRS
dc.subjectChemistry
dc.subjectChemistry, Organic
dc.subjectChemistry, Physical
dc.subjectHELICES
dc.subjectOLIGODEOXYNUCLEOTIDES
dc.subjectOLIGONUCLEOTIDES
dc.subjectPYRIMIDINES
dc.subjectRESIDUES
dc.subjectSTABILITY
dc.titleModified purine nucleosides as dangling ends of DNA duplexes: the effect of the nucleobase polarizability on stacking interactions
dc.typejournal article
dc.identifier.doi10.1039/b200077f
dc.identifier.isiISI:000174549100006
dc.description.issue4
dc.description.startpage746
dc.description.endpage750
dc.publisher.placeTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD,, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND
dcterms.isPartOf.abbreviationJ. Chem. Soc.-Perkin Trans. 2
crisitem.author.deptInstitut für Chemie neuer Materialien-
crisitem.author.deptidinstitute11-
crisitem.author.parentorgFB 05 - Biologie/Chemie-
crisitem.author.grandparentorgUniversität Osnabrück-
crisitem.author.netidRoHe783-
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