Facile synthesis of 2 `-deoxynucleoside analogs of pre Q
| Autor(en): | Ramzaeva, N Becher, G Seela, F |
Stichwörter: | BIOLOGICAL-ACTIVITY; CADEGUOMYCIN; Chemistry; Chemistry, Organic; NUCLEOSIDE-Q; nucleosides; preQ; pyrazolo[3,4-d]pyrimidines; PYRROLO<2,3-D>PYRIMIDINES; pyrrolo[2,3-d]pyrimidines; SUGAR CONFORMATION; TRANSFER-RNA | Erscheinungsdatum: | 1998 | Herausgeber: | GEORG THIEME VERLAG | Journal: | SYNTHESIS-STUTTGART | Ausgabe: | 9 | Startseite: | 1327 | Seitenende: | 1330 | Zusammenfassung: | The 2'-deoxy derivative of the naturally occurring preQ(0) nucleoside 4 as well as its pyrazolo[3,4-d]pyrimidine analog 5 were synthesized by copper-ion-mediated transformation of 7-iodo substituents of the 7-deazaguanine or 7-deaza-8-azaguanine nucleosides 2 and 3. They were converted into the corresponding 7-carboxy 10 as well as the 7-carbamoyl derivatives 11 and 12. |
ISSN: | 00397881 |
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