3-DEAZAPURINES AND 7-DEAZAPURINES - DUPLEX STABILITY OF OLIGONUCLEOTIDES CONTAINING MODIFIED ADENINE OR GUANINE BASES
DC Element | Wert | Sprache |
---|---|---|
dc.contributor.author | GREIN, T | |
dc.contributor.author | LAMPE, S | |
dc.contributor.author | MERSMANN, K | |
dc.contributor.author | ROSEMEYER, H | |
dc.contributor.author | THOMAS, H | |
dc.contributor.author | SEELA, F | |
dc.date.accessioned | 2021-12-23T16:03:04Z | - |
dc.date.available | 2021-12-23T16:03:04Z | - |
dc.date.issued | 1994 | |
dc.identifier.issn | 0960894X | |
dc.identifier.uri | https://osnascholar.ub.uni-osnabrueck.de/handle/unios/5777 | - |
dc.description.abstract | Oligonucleotide duplexes were destabilized when the purine bases of 2'-deoxyadenosine or 2'-deoxyguanosine were replaced by the corresponding 3-deazapurine (imidazo[4,5-c]pyridine) or 7-deazapurine (pyrrolo[2,3-d]pyrimidine) derivatives. Only d(AT)(6) was stabilized by incorporation of c A when high salt condition were used. The stability of deazapurine base-protecting groups was also investigated. | |
dc.language.iso | en | |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | |
dc.relation.ispartof | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | |
dc.subject | 3-DEAZA-2'-DEOXYADENOSINE | |
dc.subject | 7-DEAZA-2'-DEOXYADENOSINE | |
dc.subject | 7-DEAZA-2'-DEOXYGUANOSINE | |
dc.subject | B-DNA | |
dc.subject | Chemistry | |
dc.subject | Chemistry, Medicinal | |
dc.subject | Chemistry, Organic | |
dc.subject | OLIGODEOXYRIBONUCLEOTIDES | |
dc.subject | Pharmacology & Pharmacy | |
dc.subject | POLYNUCLEOTIDES | |
dc.subject | RECOGNITION | |
dc.subject | REPLACING DA | |
dc.subject | SOLID-PHASE SYNTHESIS | |
dc.subject | TRACTS | |
dc.title | 3-DEAZAPURINES AND 7-DEAZAPURINES - DUPLEX STABILITY OF OLIGONUCLEOTIDES CONTAINING MODIFIED ADENINE OR GUANINE BASES | |
dc.type | journal article | |
dc.identifier.doi | 10.1016/S0960-894X(01)80665-X | |
dc.identifier.isi | ISI:A1994NH74000003 | |
dc.description.volume | 4 | |
dc.description.issue | 8 | |
dc.description.startpage | 971 | |
dc.description.endpage | 976 | |
dc.publisher.place | THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB | |
dcterms.isPartOf.abbreviation | Bioorg. Med. Chem. Lett. | |
crisitem.author.dept | Institut für Chemie neuer Materialien | - |
crisitem.author.deptid | institute11 | - |
crisitem.author.parentorg | FB 05 - Biologie/Chemie | - |
crisitem.author.grandparentorg | Universität Osnabrück | - |
crisitem.author.netid | RoHe783 | - |
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geprüft am 01.06.2024