Drosophila metalloproteases in development and differentiation: The role of ADAM proteins and their relatives

Autor(en): Meyer, Heiko
Panz, Mareike
Albrecht, Stefanie
Drechsler, Maik
Wang, Shuoshuo
Huesken, Mirko
Lehmacher, Christine
Paululat, Achim 
Stichwörter: ADAM; ANGIOTENSIN-CONVERTING ENZYME; Cardiogenesis; Cell Biology; CELL-MIGRATION; Drosophila heart morphogenesis; EMS; Genetic screening; GENETIC-CONTROL; HEART DEVELOPMENT; Kuzbanian; MELANOGASTER; Meltrin; Mesoderm; MOLECULAR-CLONING; MURINE CARDIAC DEVELOPMENT; Neprilysin; NEPRILYSIN FAMILY; PERICARDIAL ORGANS; SLIT; Unc5
Erscheinungsdatum: 2011
Herausgeber: ELSEVIER GMBH, URBAN & FISCHER VERLAG
Journal: EUROPEAN JOURNAL OF CELL BIOLOGY
Volumen: 90
Ausgabe: 9
Startseite: 770
Seitenende: 778
Zusammenfassung: 
ADAM metalloproteases are membrane bound glycoproteins that control many biological processes during development and differentiation, mainly by acting as ectodomain sheddases. The Drosophila genome contains five genes that code for classical ADAM proteins which are characterized by a highly conserved domain structure with the respective catalytic domains facing the extracellular space. More than 50 genes encode related proteins such as those that have lost their primary enzymatic activity while retaining, e.g., their adhesive properties. The physiological relevance of many Drosophila ADAMs and their relatives is still unknown, however for others, a striking role during organogenesis and tissue maintenance has been demonstrated during the last few years. We have carried out genetic screenings combined with candidate approaches, aiming to identify new components involved in cardiogenesis and muscle differentiation. Herein we summarize our results with a particular focus on metalloproteases with known or potential roles in tissue differentiation. (C) 2011 Elsevier GmbH. All rights reserved.
ISSN: 01719335
DOI: 10.1016/j.ejcb.2011.04.015

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