Base pairing of 8-aza-7-deazapurine-2,6-diamine linked via the N(8)-position to the DNA backbone: Universal base-pairing properties and formation of highly stable duplexes when alternating with dT

Autor(en): He, JL
Seela, F
Stichwörter: 2,6-DIAMINOPURINE; 8-AZA-7-DEAZAADENINE; Chemistry; Chemistry, Multidisciplinary; NUCLEOSIDES; PROTECTION
Erscheinungsdatum: 2002
Herausgeber: WILEY-V C H VERLAG GMBH
Journal: HELVETICA CHIMICA ACTA
Volumen: 85
Ausgabe: 5
Startseite: 1340
Seitenende: 1354
Zusammenfassung: 
The unusually N-8-glycosylated pyrazolo[3.4-d]pyrimidine-4.6-diamine 2'-deoxyribonucleoside (3) was synthesized and converted to the phosphoramidite 11. Oligonucleotides were prepared by solid-phase synthesis. and the base pairing Of compound 3 was Studied. In non-self-complementary duplexes containing compound 3, base pairs arc formed that show located opposite to the four canonical DNA constituents, strong ambiguous pairing properties. The self-complementary duplex d(3-T)(6) (34(.)34) is significantly more stable than d(A-T)(6).
ISSN: 0018019X
DOI: 10.1002/1522-2675(200205)85:5<1340::AID-HLCA1340>3.0.CO;2-H

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