Stabilisation of duplex DNA by 7-halogenated 8-aza-7-deazaguanines

Autor(en): Seela, F
Becher, G
Stichwörter: 8-AZA-7-DEAZA-2'-DEOXYGUANOSINE; Chemistry; Chemistry, Multidisciplinary
Erscheinungsdatum: 1998
Herausgeber: ROYAL SOC CHEMISTRY
Journal: CHEMICAL COMMUNICATIONS
Ausgabe: 18
Startseite: 2017
Seitenende: 2018
Zusammenfassung: 
Oligonucleotides containing 7-halogenated 8-aza-7-deaza-2'-deoxyguanosine (c(7)z(8)G(d)) derivatives such as d(Br(7)c(7)z(8) G-C)(4) 8 (T-m = 88 degrees C) and d(I(7)c(7)z(8) G-C)(4) 9 (T-m = 84 degrees C) are significantly more stable than d(G-C)(4) 5 (T-m = 59 degrees C).
ISSN: 13597345
DOI: 10.1039/a804414g

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