O-2 `,3 `-Ketal-Nucleolipids of the Cytostatic 5-Fluorouridine: Synthesis, Lipophilicity, and Acidic Stability

Autor(en): Malecki, Edith
Rosemeyer, Helmut 
Stichwörter: 5-FLUORO-2'-DEOXYURIDINE; ACETALS; ADENOSINE; ALKYLIDENE; Chemistry; Chemistry, Multidisciplinary; FTORAFUR; IMMOBILIZATION; INOSINE
Erscheinungsdatum: 2010
Herausgeber: WILEY-V C H VERLAG GMBH
Journal: HELVETICA CHIMICA ACTA
Volumen: 93
Ausgabe: 8
Startseite: 1500
Seitenende: 1512
Zusammenfassung: 
The synthesis of a series of cyclic and acyclic O-2',3'-ketal derivatives of the cancerostatic 5-fluorourichne (2a) is described The novel compounds were characterized by H-1- and C-13-NMR, and UV spectroscopy, as well as by elemental analyses The lipophilicity values (log P. retention times in RP-18 HPLC) of the cyclic ketals were determined and related to the ring tensions as well as the acid stability of the spiro-linked ketal rings
ISSN: 0018019X
DOI: 10.1002/hlca.201000121

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