O-2 `,3 `-Ketal-Nucleolipids of the Cytostatic 5-Fluorouridine: Synthesis, Lipophilicity, and Acidic Stability
Autor(en): | Malecki, Edith Rosemeyer, Helmut |
Stichwörter: | 5-FLUORO-2'-DEOXYURIDINE; ACETALS; ADENOSINE; ALKYLIDENE; Chemistry; Chemistry, Multidisciplinary; FTORAFUR; IMMOBILIZATION; INOSINE | Erscheinungsdatum: | 2010 | Herausgeber: | WILEY-V C H VERLAG GMBH | Journal: | HELVETICA CHIMICA ACTA | Volumen: | 93 | Ausgabe: | 8 | Startseite: | 1500 | Seitenende: | 1512 | Zusammenfassung: | The synthesis of a series of cyclic and acyclic O-2',3'-ketal derivatives of the cancerostatic 5-fluorourichne (2a) is described The novel compounds were characterized by H-1- and C-13-NMR, and UV spectroscopy, as well as by elemental analyses The lipophilicity values (log P. retention times in RP-18 HPLC) of the cyclic ketals were determined and related to the ring tensions as well as the acid stability of the spiro-linked ketal rings |
ISSN: | 0018019X | DOI: | 10.1002/hlca.201000121 |
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geprüft am 03.05.2024