Synthesis and characterisation of dextran and pullulan sulphate

Autor(en): Mahner, C
Lechner, MD
Nordmeier, E
Stichwörter: Biochemistry & Molecular Biology; Chemistry; Chemistry, Applied; Chemistry, Organic; dextran sulphate; FTIR spectroscopy; NMR spectroscopy; pullulan sulphate; SULFATION
Erscheinungsdatum: 2001
Herausgeber: ELSEVIER SCI LTD
Journal: CARBOHYDRATE RESEARCH
Volumen: 331
Ausgabe: 2
Startseite: 203
Seitenende: 208
Zusammenfassung: 
Dextrans and pullulans of different molar masses in the range of 10(4)-10(5) g/mol were sulphated via a SO3-pyridine complex. The degree of substitution achieved was DS = 2.4 and DS = 1.4 for dextran sulphate and DS = 2.0 and DS = 1.4 for pullulan sulphate, respectively. Confirmation of sulphation was given by FTIR spectroscopy. Asymmetrical S=O and symmetrical C-O-S stretching vibrations were detected at 1260 and 820 cm(-1). Reactivity of the polysaccharide C-atoms was determined by C-13 NMR spectroscopy: For dextran this was C-3 > C-2 > C-4, while for pullulan it was C-6 > C-3 > C-2 > C-4. (C) 2001 Elsevier Science Ltd. All rights reserved.
ISSN: 00086215
DOI: 10.1016/S0008-6215(00)00315-3

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