2'-DEOXY-BETA-D-XYLOTHYMIDINYL-(3', 5')-2'-DEOXY-BETA-D-XYLOTHYMIDYLATE - STEREOCHEMICAL COURSE OF DINUCLEOSIDE PHOSPHONATE FORMATION AND CONFORMATIONAL PROPERTIES

DC FieldValueLanguage
dc.contributor.authorROSEMEYER, H
dc.contributor.authorSTRODTHOLZ, I
dc.contributor.authorSEELA, F
dc.date.accessioned2021-12-23T16:04:11Z-
dc.date.available2021-12-23T16:04:11Z-
dc.date.issued1992
dc.identifier.issn0960894X
dc.identifier.urihttps://osnascholar.ub.uni-osnabrueck.de/handle/unios/6306-
dc.description.abstractCoupling of 5'-DMT-protected 1-(2-deoxy-beta-D-xylofuranosyl)thymine 3'-phosphonate with 3'-benzoylated 1-(2-deoxy-beta-D-xylofuranosyl)thymine gave the diastereoisomeric dinucleoside phosphonates 4/5 with the S(P) compound in preponderance (de, 29 %). Oxidation of 4/5 (I2, H2O) and removal of the protecting groups gave d(xTpxT) which exhibits an inverted CD-spectrum compared to d(TpT) but identical stacking interactions.
dc.language.isoen
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.relation.ispartofBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
dc.subjectChemistry
dc.subjectChemistry, Medicinal
dc.subjectChemistry, Organic
dc.subjectPharmacology & Pharmacy
dc.subjectPHOSPHATES
dc.title2'-DEOXY-BETA-D-XYLOTHYMIDINYL-(3', 5')-2'-DEOXY-BETA-D-XYLOTHYMIDYLATE - STEREOCHEMICAL COURSE OF DINUCLEOSIDE PHOSPHONATE FORMATION AND CONFORMATIONAL PROPERTIES
dc.typejournal article
dc.identifier.doi10.1016/S0960-894X(00)80214-0
dc.identifier.isiISI:A1992JV33800005
dc.description.volume2
dc.description.issue10
dc.description.startpage1201
dc.description.endpage1206
dc.publisher.placeTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB
dcterms.isPartOf.abbreviationBioorg. Med. Chem. Lett.
crisitem.author.deptInstitut für Chemie neuer Materialien-
crisitem.author.deptidinstitute11-
crisitem.author.parentorgFB 05 - Biologie/Chemie-
crisitem.author.grandparentorgUniversität Osnabrück-
crisitem.author.netidRoHe783-
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