2'-DEOXY-BETA-D-XYLOTHYMIDINYL-(3', 5')-2'-DEOXY-BETA-D-XYLOTHYMIDYLATE - STEREOCHEMICAL COURSE OF DINUCLEOSIDE PHOSPHONATE FORMATION AND CONFORMATIONAL PROPERTIES
DC Element | Wert | Sprache |
---|---|---|
dc.contributor.author | ROSEMEYER, H | |
dc.contributor.author | STRODTHOLZ, I | |
dc.contributor.author | SEELA, F | |
dc.date.accessioned | 2021-12-23T16:04:11Z | - |
dc.date.available | 2021-12-23T16:04:11Z | - |
dc.date.issued | 1992 | |
dc.identifier.issn | 0960894X | |
dc.identifier.uri | https://osnascholar.ub.uni-osnabrueck.de/handle/unios/6306 | - |
dc.description.abstract | Coupling of 5'-DMT-protected 1-(2-deoxy-beta-D-xylofuranosyl)thymine 3'-phosphonate with 3'-benzoylated 1-(2-deoxy-beta-D-xylofuranosyl)thymine gave the diastereoisomeric dinucleoside phosphonates 4/5 with the S(P) compound in preponderance (de, 29 %). Oxidation of 4/5 (I2, H2O) and removal of the protecting groups gave d(xTpxT) which exhibits an inverted CD-spectrum compared to d(TpT) but identical stacking interactions. | |
dc.language.iso | en | |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | |
dc.relation.ispartof | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | |
dc.subject | Chemistry | |
dc.subject | Chemistry, Medicinal | |
dc.subject | Chemistry, Organic | |
dc.subject | Pharmacology & Pharmacy | |
dc.subject | PHOSPHATES | |
dc.title | 2'-DEOXY-BETA-D-XYLOTHYMIDINYL-(3', 5')-2'-DEOXY-BETA-D-XYLOTHYMIDYLATE - STEREOCHEMICAL COURSE OF DINUCLEOSIDE PHOSPHONATE FORMATION AND CONFORMATIONAL PROPERTIES | |
dc.type | journal article | |
dc.identifier.doi | 10.1016/S0960-894X(00)80214-0 | |
dc.identifier.isi | ISI:A1992JV33800005 | |
dc.description.volume | 2 | |
dc.description.issue | 10 | |
dc.description.startpage | 1201 | |
dc.description.endpage | 1206 | |
dc.publisher.place | THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB | |
dcterms.isPartOf.abbreviation | Bioorg. Med. Chem. Lett. | |
crisitem.author.dept | Institut für Chemie neuer Materialien | - |
crisitem.author.deptid | institute11 | - |
crisitem.author.parentorg | FB 05 - Biologie/Chemie | - |
crisitem.author.grandparentorg | Universität Osnabrück | - |
crisitem.author.netid | RoHe783 | - |
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geprüft am 17.05.2024