Lifetime development of behavioural phenotype in the house mouse (Mus musculus)

DC FieldValueLanguage
dc.contributor.authorBrust, Vera
dc.contributor.authorSchindler, Philipp M.
dc.contributor.authorLewejohann, Lars
dc.date.accessioned2021-12-23T16:04:21Z-
dc.date.available2021-12-23T16:04:21Z-
dc.date.issued2015
dc.identifier.issn17429994
dc.identifier.urihttps://osnascholar.ub.uni-osnabrueck.de/handle/unios/6389-
dc.description.abstractWith each trajectory taken during the ontogeny of an individual, the number of optional behavioural phenotypes that can be expressed across its life span is reduced. The initial range of phenotypic plasticity is largely determined by the genetic material/composition of the gametes whereas interacting with the given environment shapes individuals to adapt to/cope with specific demands. In mammalian species, the phenotype is shaped as the foetus grows, depending on the environment in the uterus, which in turn depends on the outer environment the mother experiences during pregnancy. After birth, a complex interaction between innate constitution and environmental conditions shapes individual lifetime trajectories, bringing about a wide range of diversity among individual subjects. In laboratory mice inbreeding has been systematically induced in order to reduce the genetic variability between experimental subjects. In addition, within most laboratories conducting behavioural phenotyping with mice, breeding and housing conditions are highly standardised. Despite such standardisation efforts a considerable amount of variability persists in the behaviour of mice. There is good evidence that phenotypic variation is not merely random but might involve individual specific behavioural patterns consistent over time. In order to understand the mechanisms and the possible adaptive value of the maintenance of individuality we review the emergence of behavioural phenotypes over the course of the life of (laboratory) mice. We present a literature review summarizing developmental stages of behavioural development of mice along with three illustrative case studies. We conclude that the accumulation of environmental differences and experiences lead to a ``mouse individuality'' that becomes increasingly stable over the lifetime.
dc.description.sponsorshipGerman Research FoundationGerman Research Foundation (DFG) [FOR 1232, LE 2356/40-1]; We would like to thank Norbert Sachser for granting access to data obtained in the Department of Behavioural Biology of the University of Muenster, Germany. This work was funded by the German Research Foundation (FOR 1232; LE 2356/40-1).
dc.language.isoen
dc.publisherBMC
dc.relation.ispartofFRONTIERS IN ZOOLOGY
dc.subjectADOLESCENT BRAIN
dc.subjectAGE-RELATED-CHANGES
dc.subjectINBRED STRAINS
dc.subjectINDIVIDUAL-DIFFERENCES
dc.subjectLABORATORY MICE
dc.subjectMATERNAL-CARE
dc.subjectPERSONALITY-DEVELOPMENT
dc.subjectPRENATAL STRESS
dc.subjectSEXUAL-MATURATION
dc.subjectSOCIAL-FACTORS
dc.subjectZoology
dc.titleLifetime development of behavioural phenotype in the house mouse (Mus musculus)
dc.typereview
dc.identifier.doi10.1186/1742-9994-12-S1-S17
dc.identifier.isiISI:000363472300017
dc.description.volume12
dc.description.issue1
dc.contributor.orcid0000-0002-0202-4351
dc.contributor.orcid0000-0003-4128-4495
dc.contributor.researcheridH-3717-2013
dc.contributor.researcheridAAQ-9324-2021
dc.publisher.placeCAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
dcterms.isPartOf.abbreviationFront. Zool.
dcterms.oaStatusGreen Published, gold
crisitem.author.deptFB 05 - Biologie/Chemie-
crisitem.author.deptidfb05-
crisitem.author.orcid0000-0002-0202-4351-
crisitem.author.parentorgUniversität Osnabrück-
crisitem.author.netidLeLa611-
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