How do I begin? Sensing extracellular stress to maintain yeast cell wall integrity

Autor(en): Jendretzki, Arne
Wittland, Janina
Wilk, Sabrina
Straede, Andrea
Heinisch, Juergen J.
Stichwörter: Cell Biology; EXPRESSION; FAMILY; GENE; IDENTIFICATION; MAP kinase cascade; Mechanosensor; MID2; PROTEIN-KINASE-C; Saccharomyces cerevisiae; SACCHAROMYCES-CEREVISIAE; SIGNALING PATHWAYS; SURFACE SENSORS; WSC1; Wsc2
Erscheinungsdatum: 2011
Herausgeber: ELSEVIER GMBH, URBAN & FISCHER VERLAG
Journal: EUROPEAN JOURNAL OF CELL BIOLOGY
Volumen: 90
Ausgabe: 9
Startseite: 740
Seitenende: 744
Zusammenfassung: 
The cell wall integrity (CWI) signalling pathway is necessary to remodel the yeast cell wall during normal morphogenesis and in response to cell surface stress. In the Baker's yeast Saccharomyces cerevisiae, a set of five membrane-spanning sensors, namely Wsc1, Wsc2, Wsc3, Mid2 and Mtl1, detect perturbations in the cell wall and/or the plasma membrane and activate a downstream signal transduction pathway with a central MAP kinase module. As a consequence, the expression of genes whose products are involved in cell wall structure and remodelling is induced. This review summarises our recent results on sensor structure and function, as well as the advances made regarding sensor mechanics. (C) 2011 Elsevier GmbH. All rights reserved.
ISSN: 01719335
DOI: 10.1016/j.ejcb.2011.04.006

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