Hardening-effect .2. Experimental induction due to irritants.

Autor(en): Wulfhorst, B
Stichwörter: Allergy; BARRIER FUNCTION; bioengineering methods; Excited-Skin-Syndrome; hardening-effect; HUMAN SKIN; irritant inflammatory response; LANGERHANS CELLS; LASER-DOPPLER FLOWMETRY; OF-CONTACT-DERMATITIS; PERMEABILITY BARRIER; skin-irritability-research; SODIUM LAURYL SULFATE; STANDARDIZATION-GROUP; SUSCEPTIBILITY; TRANSEPIDERMAL WATER-LOSS; zytocines
Erscheinungsdatum: 1996
Volumen: 19
Ausgabe: 12
Startseite: 541
Seitenende: 549
The possibility of inducing a Hardening-effect by irritants has been studied with bioengineering methods. In a first phase of the study (P1) the TEWL and the blood-flow were measured, sodium-lauryl-sulphate (SLS) in different concentrations and Aceton (100%) were applicated daily for 3 weeks (monday - friday) on the right volar forearms of 20 volunteers. Three weeks after the end of P1 the repetitive irritation was continued one more week (P2). In this phase the irritants were applicated on the same test-areals as in P1 and additional on contralateral test-sides on the left forearm. In P1 the values for the blood-flow were stabil within the second week. Comparing the baseline TEWL-values of day 1 in P1 and P2, there were significant differences with higher values in the second phase for both arms. Differences in the reagibility of the pre-treated and the not-pretreated test sides after irritation were not seen. The TEWL-values for the second phase in relation to those of the first phase (day 1 - 5) have increased procentually less. Moreover it is shown that there are constitutional differences in the reaction to repetitive irritation between atopics and non-atopics. In this coherence systemic effects in the sense of an Excited-Skin-Syndrome and a following hypoirritability are to be discussed. On the other hand there is the question of whether the intervals of increasing values are the same at low and high baseline TEWL-values.
ISSN: 03445062

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